Rankings
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Fulham | 7 | 5 | 1 | 1 | 17 | 5 | +12 | 16 |
| 2 |  West Bromwich Albion |
7 | 4 | 3 | 0 | 13 | 6 | +7 | 15 |
| 3 |  AFC Bournemouth |
7 | 4 | 3 | 0 | 13 | 6 | +7 | 15 |
| 4 | Coventry City | 7 | 5 | 0 | 2 | 8 | 5 | +3 | 15 |
| 5 |  Stoke City |
7 | 4 | 2 | 1 | 10 | 8 | +2 | 14 |
| 6 | Huddersfield Town | 7 | 4 | 1 | 2 | 13 | 9 | +4 | 13 |
| 7 | Queens Park Rangers | 7 | 3 | 3 | 1 | 15 | 10 | +5 | 12 |
| 8 | Blackburn Rovers | 7 | 3 | 3 | 1 | 11 | 8 | +3 | 12 |
| 9 | Cardiff City | 7 | 3 | 2 | 2 | 11 | 8 | +3 | 11 |
| 10 | Birmingham City | 7 | 3 | 2 | 2 | 10 | 7 | +3 | 11 |
| 11 | Middlesbrough | 7 | 2 | 3 | 2 | 8 | 8 | +0 | 9 |
| 12 | Bristol City | 7 | 2 | 3 | 2 | 8 | 8 | +0 | 9 |
| 13 | Luton Town | 7 | 2 | 3 | 2 | 9 | 11 | -2 | 9 |
| 14 | Preston North End | 7 | 2 | 2 | 3 | 8 | 10 | -2 | 8 |
| 15 | Millwall | 7 | 1 | 4 | 2 | 7 | 9 | -2 | 7 |
| 16 | Derby County | 7 | 1 | 4 | 2 | 4 | 6 | -2 | 7 |
| 17 | Barnsley | 7 | 1 | 4 | 2 | 6 | 9 | -3 | 7 |
| 18 | Reading | 7 | 2 | 1 | 4 | 13 | 17 | -4 | 7 |
| 19 | Sheffield United | 7 | 1 | 3 | 3 | 9 | 11 | -2 | 6 |
| 20 |  Swansea City |
7 | 1 | 3 | 3 | 4 | 8 | -4 | 6 |
| 21 | Hull City | 7 | 1 | 2 | 4 | 4 | 9 | -5 | 5 |
| 22 | Blackpool | 7 | 1 | 2 | 4 | 5 | 11 | -6 | 5 |
| 23 | Peterborough U… | 7 | 1 | 1 | 5 | 7 | 17 | -10 | 4 |
| 24 | Nottingham Forest | 7 | 0 | 1 | 6 | 5 | 12 | -7 | 1 |
Fixtures
| September 18, 2021 | ||
| Hull City | 11:30 | Sheffield United |
| Barnsley | 14:00 | Blackburn Rovers |
| Cardiff City | 14:00 | AFC Bournemouth |
| Derby County | 14:00 | Stoke City |
| Fulham | 14:00 | Reading |
| Huddersfield Town | 14:00 | Nottingham Forest |
| Luton Town | 14:00 | Swansea City |
| Middlesbrough | 14:00 | Blackpool |
| Millwall | 14:00 | Coventry City |
| Peterborough U… | 14:00 | Birmingham City |
| Preston North End | 14:00 | West Bromwich Albion |
| Queens Park Rangers | 14:00 | Bristol City |
| September 24, 2021 | ||
| Coventry City | 18:45 | Peterborough U… |
| West Bromwich Albion |
19:00 | Queens Park Rangers |
Results
| September 15, 2021 | ||
| Swansea City |
0 - 0 | Millwall |
| Birmingham City | 1 - 4 | Fulham |
| Stoke City |
1 - 1 | Barnsley |
| Nottingham Forest | 0 - 2 | Middlesbrough |
| Coventry City | 1 - 0 | Cardiff City |
| Bristol City | 1 - 1 | Luton Town |
| September 14, 2021 | ||
| Reading | 3 - 1 | Peterborough U… |
| West Bromwich Albion |
0 - 0 | Derby County |
| Sheffield United | 2 - 2 | Preston North End |
| Blackpool | 0 - 3 | Huddersfield Town |
| Blackburn Rovers | 2 - 0 | Hull City |
| AFC Bournemouth |
2 - 1 | Queens Park Rangers |
| September 12, 2021 | ||
| Nottingham Forest | 1 - 2 | Cardiff City |