Rankings
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Montréal | 11 | 6 | 2 | 3 | 22 | 19 | +3 | 20 |
| 2 |  Orlando City |
12 | 6 | 2 | 4 | 14 | 15 | -1 | 20 |
| 3 |  Philadelphia Union |
11 | 5 | 5 | 1 | 16 | 9 | +7 | 20 |
| 4 | Cincinnati | 12 | 6 | 1 | 5 | 16 | 18 | -2 | 19 |
| 5 |  New York RB |
11 | 5 | 4 | 2 | 17 | 9 | +8 | 19 |
| 6 |  New York City |
10 | 5 | 2 | 3 | 21 | 10 | +11 | 17 |
| 7 | Atlanta United | 11 | 4 | 3 | 4 | 17 | 16 | +1 | 15 |
| 8 | D.C. United | 10 | 4 | 1 | 5 | 14 | 15 | -1 | 13 |
| 9 | Charlotte | 12 | 4 | 1 | 7 | 10 | 15 | -5 | 13 |
| 10 |  Columbus Crew |
11 | 3 | 4 | 4 | 15 | 13 | +2 | 13 |
| 11 |  New England |
11 | 3 | 3 | 5 | 18 | 20 | -2 | 12 |
| 12 |  Toronto |
12 | 3 | 2 | 7 | 16 | 23 | -7 | 11 |
| 13 | Inter Miami | 11 | 3 | 2 | 6 | 11 | 21 | -10 | 11 |
| 14 |  Chicago Fire |
11 | 2 | 4 | 5 | 8 | 13 | -5 | 10 |
Fixtures
| May 18, 2022 | ||
| D.C. United | 23:30 | New York City |
| New York RB |
23:30 | Chicago Fire |
| Philadelphia Union |
23:30 | Inter Miami |
| May 19, 2022 | ||
| Minnesota United | 00:00 |  LA Galaxy |
Houston Dynamo  |
00:30 |  Seattle Sounders |
Sporting KC  |
00:30 |  Colorado Rapids |
| Nashville SC | 00:30 | Montréal |
| Vancouver Whitecaps FC | 02:00 |  Dallas |
| Los Angeles | 02:30 | Austin |
SJ Earthquakes  |
02:30 |  Portland Timbers |
| May 21, 2022 | ||
| Columbus Crew |
19:30 | Los Angeles |
| D.C. United | 20:00 | Toronto |
| Cincinnati | 22:00 | New England |
| Nashville SC | 23:30 | Atlanta United |
| May 22, 2022 | ||
| Montréal | 20:00 |  Real Salt Lake |
| Charlotte | 21:00 | Vancouver Whitecaps FC |
| New York City |
21:00 | Chicago Fire |
Results
| May 15, 2022 | ||
| Seattle Sounders |
3 - 1 | Minnesota United |
| Atlanta United | 2 - 2 | New England |
| LA Galaxy |
1 - 3 | Dallas |
| Portland Timbers |
7 - 2 | Sporting KC |
| Real Salt Lake |
2 - 1 | Austin |
| Inter Miami | 2 - 2 | D.C. United |
| Houston Dynamo |
2 - 0 | Nashville SC |
| Chicago Fire |
1 - 2 | Cincinnati |
| May 14, 2022 | ||
| Philadelphia Union |
1 - 1 | New York RB |
| Vancouver Whitecaps FC | 3 - 3 | SJ Earthquakes |
| New York City |
2 - 0 | Columbus Crew |
| Charlotte | 0 - 2 | Montréal |
| Colorado Rapids |
2 - 0 | Los Angeles |
| Toronto |
0 - 1 | Orlando City |
| May 8, 2022 | ||
| Austin | 0 - 1 | LA Galaxy |