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Rankings
| # |
Team |
MP |
W |
D |
L |
F |
A |
G |
P |
| 1 |
Plaza Colonia |
15 |
11 |
3 |
1 |
20 |
7 |
+13 |
36 |
| 2 |
Nacional |
15 |
9 |
2 |
4 |
23 |
14 |
+9 |
29 |
| 3 |
Peñarol |
15 |
7 |
7 |
1 |
22 |
10 |
+12 |
28 |
| 4 |
 Liverpool |
15 |
8 |
3 |
4 |
38 |
20 |
+18 |
27 |
| 5 |
River Plate |
15 |
7 |
5 |
3 |
27 |
20 |
+7 |
26 |
| 6 |
City Torque |
15 |
8 |
1 |
6 |
26 |
19 |
+7 |
25 |
| 7 |
Fénix |
15 |
6 |
3 |
6 |
20 |
22 |
-2 |
21 |
| 8 |
Cerro Largo |
15 |
6 |
2 |
7 |
20 |
22 |
-2 |
20 |
| 9 |
Cerrito |
15 |
5 |
4 |
6 |
14 |
15 |
-1 |
19 |
| 10 |
Sud América |
15 |
5 |
3 |
7 |
15 |
22 |
-7 |
18 |
| 11 |
Wanderers |
15 |
5 |
2 |
8 |
12 |
16 |
-4 |
17 |
| 12 |
Rentistas |
15 |
4 |
4 |
7 |
12 |
21 |
-9 |
16 |
| 13 |
Boston River |
15 |
3 |
5 |
7 |
14 |
19 |
-5 |
14 |
| 14 |
Deportivo Mald… |
15 |
3 |
5 |
7 |
11 |
22 |
-11 |
14 |
| 15 |
Progreso |
15 |
2 |
5 |
8 |
13 |
26 |
-13 |
11 |
| 16 |
Villa Española |
15 |
1 |
6 |
8 |
14 |
26 |
-12 |
9 |
Fixtures
| October 1, 2021 |
| Deportivo Mald… |
19:00 |
Rentistas |
| October 2, 2021 |
| Cerrito |
00:15 |
Sud América |
| Villa Española |
16:15 |
Fénix |
| River Plate |
18:30 |
Cerro Largo |
| October 3, 2021 |
| Liverpool |
15:30 |
Progreso |
| Nacional |
18:30 |
Plaza Colonia |
| City Torque |
21:00 |
Boston River |
| October 4, 2021 |
| Peñarol |
00:00 |
Wanderers |
Results
| September 26, 2021 |
| Wanderers |
2 - 1 |
Rentistas |
| Boston River |
2 - 5 |
Peñarol |
| Fénix |
1 - 1 |
City Torque |
| Progreso |
0 - 1 |
Cerrito |
| September 25, 2021 |
| Sud América |
0 - 2 |
Nacional |
| Cerro Largo |
3 - 0 |
Liverpool |
| River Plate |
1 - 2 |
Deportivo Mald… |
| September 24, 2021 |
| Plaza Colonia |
4 - 0 |
Villa Española |
| September 20, 2021 |
| Deportivo Mald… |
1 - 3 |
Wanderers |
| September 19, 2021 |
| City Torque |
2 - 2 |
Plaza Colonia |
| Nacional |
0 - 1 |
Progreso |
| Liverpool |
3 - 1 |
River Plate |
| September 18, 2021 |
| Villa Española |
1 - 2 |
Sud América |
| Cerrito |
1 - 1 |
Cerro Largo |
| September 17, 2021 |
| Peñarol |
0 - 0 |
Fénix |
| Rentistas |
1 - 2 |
Boston River |
| September 13, 2021 |
| Progreso |
1 - 1 |
Villa Española |
| Liverpool |
1 - 0 |
Deportivo Mald… |