Rankings
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina | 30 | 13 | 8 | 9 | 44 | 32 | +12 | 47 |
| 2 | Whitecaps (USSF) | 30 | 10 | 15 | 5 | 32 | 22 | +10 | 45 |
| 3 | Impact | 30 | 12 | 7 | 11 | 36 | 30 | +6 | 43 |
| 4 | Fort Lauderdal… | 30 | 7 | 12 | 11 | 37 | 49 | -12 | 33 |
| 5 | St. Louis | 30 | 7 | 8 | 15 | 32 | 48 | -16 | 29 |
| 6 | Crystal Palac… | 30 | 6 | 6 | 18 | 24 | 55 | -31 | 24 |
Fixtures
Results
| October 30, 2010 | ||
| North Carolina | 1 - 1 | Puerto Rico Is… |
| October 24, 2010 | ||
| Puerto Rico Is… | 2 - 0 | North Carolina |
| October 17, 2010 | ||
| Whitecaps (USSF) | 0 - 0 | Puerto Rico Is… |
| North Carolina | 2 - 0 | Impact |
| October 14, 2010 | ||
| Puerto Rico Is… | 0 - 0 | Whitecaps (USSF) |
| Impact | 1 - 0 | North Carolina |
| October 11, 2010 | ||
| Portland Timbe… | 1 - 0 | Whitecaps (USSF) |
| October 9, 2010 | ||
Orlando City  |
2 - 3 | Impact |
| Rochester New York | 2 - 1 | Puerto Rico Is… |
| North Carolina | 4 - 0 | Minnesota United |
| October 8, 2010 | ||
| Whitecaps (USSF) | 2 - 0 | Portland Timbe… |
| October 7, 2010 | ||
| Puerto Rico Is… | 2 - 0 | Rochester New York |
| October 6, 2010 | ||
| Minnesota United | 0 - 0 | North Carolina |
| Impact | 2 - 0 | Orlando City |
| October 3, 2010 | ||
| Impact | 2 - 0 | Orlando City |
| St. Louis | 1 - 2 | Rochester New York |
| October 2, 2010 | ||
| Fort Lauderdal… | 1 - 1 | Puerto Rico Is… |
| Whitecaps (USSF) | 2 - 2 | Portland Timbe… |
| October 1, 2010 | ||
| Tampa Bay Rowdies | 6 - 3 | Crystal Palac… |
| North Carolina | 3 - 1 | Orlando City |