Rankings
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Inter Miami | 11 | 6 | 3 | 2 | 26 | 16 | +10 | 21 |
| 2 | Cincinnati | 10 | 5 | 3 | 2 | 12 | 9 | +3 | 18 |
| 3 |  New York RB |
10 | 4 | 5 | 1 | 14 | 10 | +4 | 17 |
| 4 |  Toronto |
10 | 5 | 1 | 4 | 11 | 13 | -2 | 16 |
| 5 |  Columbus Crew |
10 | 3 | 6 | 1 | 12 | 9 | +3 | 15 |
| 6 |  New York City |
10 | 4 | 2 | 4 | 11 | 10 | +1 | 14 |
| 7 |  Philadelphia Union |
8 | 3 | 4 | 1 | 15 | 11 | +4 | 13 |
| 8 | D.C. United | 10 | 3 | 4 | 3 | 14 | 15 | -1 | 13 |
| 9 | Atlanta United | 9 | 3 | 3 | 3 | 13 | 9 | +4 | 12 |
| 10 | Montréal | 9 | 3 | 3 | 3 | 12 | 16 | -4 | 12 |
| 11 | Charlotte | 10 | 3 | 2 | 5 | 10 | 13 | -3 | 11 |
| 12 |  Chicago Fire |
10 | 2 | 4 | 4 | 11 | 18 | -7 | 10 |
| 13 |  Orlando City |
9 | 2 | 3 | 4 | 11 | 17 | -6 | 9 |
| 14 | Nashville SC | 9 | 1 | 5 | 3 | 10 | 17 | -7 | 8 |
| 15 |  New England |
9 | 1 | 1 | 7 | 6 | 18 | -12 | 4 |
Fixtures
| April 30, 2024 | ||
| Philadelphia Union |
23:30 |  Seattle Sounders |
| May 4, 2024 | ||
| Orlando City |
23:30 | Cincinnati |
| Toronto |
23:30 |  Dallas |
SJ Earthquakes  |
23:30 | Los Angeles |
| Atlanta United | 23:30 | Minnesota United |
| Inter Miami | 23:30 | New York RB |
| D.C. United | 23:30 | Philadelphia Union |
| Charlotte | 23:30 |  Portland Timbers |
| May 5, 2024 | ||
| Chicago Fire |
00:30 | New England |
Houston Dynamo  |
00:30 | St. Louis City |
| Nashville SC | 00:30 | Montréal |
Real Salt Lake  |
01:30 |  Sporting KC |
| Vancouver Whitecaps FC | 02:30 | Austin |
| New York City |
20:00 |  Colorado Rapids |
| Seattle Sounders |
22:45 |  LA Galaxy |
Results
| April 28, 2024 | ||
| Los Angeles | 3 - 2 | Portland Timbers |
| Nashville SC | 1 - 1 | SJ Earthquakes |
| Minnesota United | 2 - 1 | Sporting KC |
| Dallas |
2 - 0 | Houston Dynamo |
| Chicago Fire |
0 - 0 | Atlanta United |
| April 27, 2024 | ||
| New England |
1 - 4 | Inter Miami |
| Cincinnati | 2 - 1 | Colorado Rapids |
| Columbus Crew |
0 - 0 | Montréal |
| D.C. United | 2 - 1 | Seattle Sounders |
| New York City |
2 - 1 | Charlotte |
| New York RB |
1 - 1 | Vancouver Whitecaps FC |
| Orlando City |
1 - 2 | Toronto |
| Philadelphia Union |
1 - 2 | Real Salt Lake |
| Austin | 2 - 0 | LA Galaxy |
| April 22, 2024 | ||
| LA Galaxy |
4 - 3 | SJ Earthquakes |
| April 21, 2024 | ||
| Charlotte | 0 - 3 | Minnesota United |