Rankings
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Inter Miami | 10 | 5 | 3 | 2 | 22 | 15 | +7 | 18 |
| 2 |  New York RB |
9 | 4 | 4 | 1 | 13 | 9 | +4 | 16 |
| 3 | Cincinnati | 9 | 4 | 3 | 2 | 10 | 8 | +2 | 15 |
| 4 |  Columbus Crew |
9 | 3 | 5 | 1 | 12 | 9 | +3 | 14 |
| 5 |  Toronto |
9 | 4 | 1 | 4 | 9 | 12 | -3 | 13 |
| 6 |  Philadelphia Union |
7 | 3 | 4 | 0 | 14 | 9 | +5 | 13 |
| 7 | Atlanta United | 8 | 3 | 2 | 3 | 13 | 9 | +4 | 11 |
| 8 |  New York City |
9 | 3 | 2 | 4 | 9 | 9 | +0 | 11 |
| 9 | Charlotte | 9 | 3 | 2 | 4 | 9 | 11 | -2 | 11 |
| 10 | Montréal | 8 | 3 | 2 | 3 | 12 | 16 | -4 | 11 |
| 11 | D.C. United | 9 | 2 | 4 | 3 | 12 | 14 | -2 | 10 |
| 12 |  Orlando City |
8 | 2 | 3 | 3 | 10 | 15 | -5 | 9 |
| 13 |  Chicago Fire |
9 | 2 | 3 | 4 | 11 | 18 | -7 | 9 |
| 14 | Nashville SC | 8 | 1 | 4 | 3 | 9 | 16 | -7 | 7 |
| 15 |  New England |
8 | 1 | 1 | 6 | 5 | 14 | -9 | 4 |
Fixtures
| April 27, 2024 | ||
| Austin | 17:45 |  LA Galaxy |
| New York City |
23:30 | Charlotte |
| Philadelphia Union |
23:30 |  Real Salt Lake |
| Orlando City |
23:30 | Toronto |
| Cincinnati | 23:30 |  Colorado Rapids |
| New York RB |
23:30 | Vancouver Whitecaps FC |
| Columbus Crew |
23:30 | Montréal |
| New England |
23:30 | Inter Miami |
| D.C. United | 23:30 |  Seattle Sounders |
| April 28, 2024 | ||
| Nashville SC | 00:30 |  SJ Earthquakes |
| Chicago Fire |
00:30 | Atlanta United |
| Minnesota United | 00:30 |  Sporting KC |
Dallas  |
00:30 |  Houston Dynamo |
| Los Angeles | 02:30 |  Portland Timbers |
| April 30, 2024 | ||
| Philadelphia Union |
23:30 | Seattle Sounders |
Results
| April 22, 2024 | ||
| LA Galaxy |
4 - 3 | SJ Earthquakes |
| April 21, 2024 | ||
| Charlotte | 0 - 3 | Minnesota United |
| Seattle Sounders |
0 - 2 | Vancouver Whitecaps FC |
| Los Angeles | 2 - 2 | New York RB |
| Colorado Rapids |
2 - 1 | Dallas |
| Sporting KC |
3 - 3 | St. Louis City |
| Houston Dynamo |
0 - 1 | Austin |
| Chicago Fire |
0 - 4 | Real Salt Lake |
| April 20, 2024 | ||
| Toronto |
1 - 0 | New England |
| New York City |
2 - 0 | D.C. United |
| Montréal | 2 - 2 | Orlando City |
| Inter Miami | 3 - 1 | Nashville SC |
| Columbus Crew |
2 - 2 | Portland Timbers |
| Atlanta United | 1 - 2 | Cincinnati |